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目的探讨丙基硫氧嘧啶联合地塞米松治疗甲状腺功能亢进(甲亢)的临床疗效。方法将昆山市第一人民医院2011年8月至2012年12月收治的50例甲亢患者分为治疗组和对照组,对照组采用丙基硫氧嘧啶治疗,治疗组在对照组的基础上采用局部注射地塞米松治疗,两组均以8周为一个疗程,比较两组的治疗效果。结果治疗组治疗后的甲状腺体积、总三碘甲状腺原氮酸(TT3)、总甲状腺激素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)显著优于对照组(P<0.05);且治疗组的症状缓解时间、各指标恢复正常时间显著短于对照组(P<0.05)。结论丙基硫氧嘧啶联合地塞米松治疗甲亢疗效满意,值得临床推广。
Objective To investigate the clinical efficacy of propylthiouracil combined with dexamethasone in the treatment of hyperthyroidism (hyperthyroidism). Methods 50 patients with hyperthyroidism who were treated in First People’s Hospital of Kunshan from August 2011 to December 2012 were divided into treatment group and control group, while those in control group were treated with propylthiouracil. The treatment group was used on the basis of the control group Local injection of dexamethasone treatment, both groups were 8 weeks for a course of treatment, the treatment effect was compared between the two groups. Results Thyroid volume, total thyroxine (TT3), total thyroid hormone (TT4), free triiodothyronine (FT3) and free thyroxine (FT4) in the treatment group were significantly better than those in the control group P <0.05). And the time to relieve the symptoms and the normal time of each index in the treatment group were significantly shorter than those in the control group (P <0.05). Conclusions Propylthiouracil and dexamethasone are effective in treating hyperthyroidism and are worthy of clinical promotion.