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目的:观察利巴韦林与维生素B2联合喷雾治疗小儿疱疹性咽峡炎的疗效及安全性。方法:将173例符合疱疹性咽峡炎诊断条件的患儿,随机分为观察组87例和对照组86例,两组均给予相同的常规治疗,观察组同时给予利巴韦林与维生素B2混合溶液咽部喷雾治疗,以退热时间与咽部疱疹、溃疡愈合时间及总有效率作为客观评价指标。结果:观察组与对照组退热时间(h)分别为39.5±8.3、50.7±10.6(t=7.72,P<0.01);咽部病变愈合时间(天)分别为3.2±0.7、4.5±0.9(t=10.83,P<0.01);总有效率:观察组95.4%,对照组73.3%(χ2=10.56,P<0.01)。结论:利巴韦林与维生素B2联合喷雾治疗小儿疱疹性咽峡炎效果良好,无不良反应。
Objective: To observe the efficacy and safety of ribavirin combined with vitamin B2 in the treatment of pediatric herpangina. Methods: A total of 173 children with herpes simplex angina were divided randomly into observation group (87 cases) and control group (86 cases). Both groups were given the same routine treatment. The observation group was given ribavirin and vitamin B2 The mixed solution of pharyngeal spray treatment, antipyretic time and pharyngeal herpes, ulcer healing time and the total effective rate as an objective evaluation. Results: The time of fever (h) in observation group and control group were 39.5 ± 8.3 and 50.7 ± 10.6, respectively (t = 7.72, P <0.01), and the healing time of pharyngeal lesions was 3.2 ± 0.7 and 4.5 ± 0.9 respectively t = 10.83, P <0.01). The total effective rate was 95.4% in the observation group and 73.3% in the control group (χ2 = 10.56, P <0.01). Conclusion: Ribavirin and vitamin B2 combined with spray treatment of children with herpes angina have a good effect, no adverse reactions.