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给新西兰大白兔分别喂１％ 胆固醇食（ｎ＝ １９）和标准食（ｎ＝ １５）共５ 周，测定了血脂和低密度脂蛋白（ＬＤＬ）中的脂质过氧化物（ＬＰＯ）含量，并制成氧化型ＬＤＬ（ｏｘＬＤＬ），提取ｏｘＬＤＬ中的脂质进行薄层层析，并制成脑缺血模型，观察丹参抗脑缺血损伤的作用。结果：胆固醇食组兔血清胆固醇（ＣＨ）、磷脂（ＰＬ）、游离脂肪酸（ＦＦＡ）以及血浆和ＬＤＬ中ＬＰＯ 含量均显著高于标准食组（Ｐ＜ ０．０１）；胆固醇食兔ＬＤＬ和Ｃｕ２＋ 透析后的ｏｘＬＤＬ中的脂质成分发生变化，Ｘ 带增加，ＦＦＡ 带增高，而胆固醇酯（ＣＥ）带及ＴＣ带显著减少，而且丹参透析组脂质成分变化不显著，丹参组缺血后海马超微结构损伤较盐水组轻。表明，长期高胆固醇饮食可引起较多的ＬＰＯ和ｏｘＬＤＬ生成，从而加速动脉粥样硬化的形成；Ｘ 带可作为脂质过氧化的一个指标，丹参具有拮抗ＬＤＬ 氧化的作用，这是其对抗脑缺血损伤的机制之一。
New Zealand white rabbits were fed 1% cholesterol diet (n = 19) and standard diet (n = 15) for 5 weeks, and lipid peroxide (LPO) levels in blood lipids and low-density lipoprotein (LDL) were determined. And made oxidized LDL (oxLDL), extracted lipids in oxLDL thin layer chromatography, and made a model of cerebral ischemia to observe the role of Salvia miltiorrhiza against cerebral ischemia. RESULTS: Serum cholesterol (CH), phospholipids (PL), free fatty acids (FFA), and LPO levels in plasma and LDL were significantly higher in the cholesterol-eating group than in the standard group (P<0.01); cholesterol-eating cholesterol LDL and Cu2+ The lipid composition in oxLDL after dialysis changed, the X band increased, the FFA band increased, and the cholesteryl ester (CE) band and TC band decreased significantly, and the lipid composition of the Salvia miltiorrhiza dialysis group did not change significantly. Salvia miltiorrhiza group was post-ischemic hippocampus Ultrastructure damage is lighter than saline. It shows that long-term high-cholesterol diet can cause more LPO and oxLDL production, thereby accelerating the formation of atherosclerosis; X-band can be used as an indicator of lipid peroxidation, and Salvia miltiorrhiza can antagonize the oxidation of LDL, which is its resistance to brain. One of the mechanisms of ischemic injury.