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目的 :观察不同类型冠状动脉病变介入治疗前后血清淀粉样物质A(SAA)及心肌肌钙蛋白I(cTnI)的变化特点。方法 :选取接受冠状动脉介入治疗的患者 4 9例 ,按 1988年ACC/AHA专家组分类法 ,分为A、B、C三型 ,三型均于术中记录球囊扩张时间、球囊最大充盈压 (MIP)、扩张次数及造影剂用量 ,并于术前 ,术后 1、6、2 4、4 8h检测SAA、cTnI水平。结果 :A型病变组球囊扩张时间、MIP、扩张次数及造影剂用量均明显小于B、C型病变组 ,B型病变组球囊扩张时间、扩张次数及造影剂用量小于C型病变组。A型病变各时点SAA水平均高于术前且均小于同时点B、C两组水平 ;术后 2 4hA型病变组cTnI水平明显低于B、C型病变组。结论 :复杂病变患者介入治疗后SAA、cTnI水平升高明显 ,应考虑进一步给予药物辅助治疗改善预后
Objective: To observe the changes of serum amyloid A (SAA) and cardiac troponin I (cTnI) before and after the interventional treatment of different types of coronary lesions. Methods: Forty-nine patients undergoing PCI were divided into A, B, and C groups according to the 1988 ACC / AHA classification method. All the three types recorded the time of balloon dilation and the largest balloon Filling pressure (MIP), the number of dilation and the amount of contrast agent. The levels of SAA and cTnI were detected at preoperative and postoperative 1, 6, 2, 4 and 8 hours. Results: The time of balloon dilation, the number of MIP, the number of dilation and the amount of contrast agent in type A lesion group were significantly less than those in type B and C lesion group. The time of balloon dilation, the number of dilation and the amount of contrast medium in type B lesion group were less than those in type C lesion group. The level of SAA in type A lesions at each time point was significantly higher than that in type B lesions at the same time point and both at the same time points. The level of cTnI in type A lesions at 24 hours after operation was significantly lower than that in type B and C lesions. Conclusion: The levels of SAA and cTnI in patients with complex lesions increased significantly after interventional therapy, and further adjuvant therapy should be considered to improve the prognosis