CD4+杀伤性T细胞是一群表达颗粒酶和穿孔素并通过其释放发挥直接杀伤作用的CD4+T细胞群。早期关于CD4+杀伤性T细胞的研究主要集中于体外培养环境中诱导出的杀伤性细胞。但是近年来逐渐发现其在很多病毒感染性疾病和肿瘤性疾病中发挥着重要作用。更好的理解其功能特点和作用机制,将为研发新的抗感染和抗肿瘤疫苗和新的免疫治疗策略提供思路。 CD4 + killer T cells are a population of CD4 + T cells that express granzyme and perforin and exert a direct killing effect through their release. Earlier studies on CD4 + killer T cells focused on killer cells induced in the in vitro culture environment. However, it has been gradually found in recent years that it plays an important role in many viral infectious diseases and neoplastic diseases. A better understanding of its functional features and mechanisms of action will provide insights into developing new anti-infective and anti-tumor vaccines and new immunotherapy strategies.