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为研究2,4-二硝基苯甲醚(DNAN)的急性毒性和安全性,按照《化学品毒性鉴定技术规范》要求,对60只SPF级SD大鼠和8只白色家兔分别进行急性毒性试验及皮肤和眼刺激试验。结果显示,DNAN对大鼠经口LD50为109.36 mg/kg(95%CI:99.07~120.71 mg/kg);对家兔皮肤刺激后72 h内有不同程度的红斑和水肿,皮肤刺激总积分均值为0.5分;对家兔眼睛刺激后出现结膜充血、水肿、角膜受损,72 h后症状消失,眼刺激总积分均值最高为3.5分。提示DNAN按急性毒性剂量分级属中等毒性物质,对皮肤、眼睛有轻微刺激性。
In order to study the acute toxicity and safety of 2,4-dinitroanisole (DNAN), 60 SPF SD rats and 8 white rabbits were randomly divided into two groups according to the requirement of Technical Specifications for Toxicity Identification of Chemicals Toxicity tests and skin and eye irritation tests. The results showed that the oral LD50 of DNAN in rats was 109.36 mg / kg (95% CI: 99.07 ~ 120.71 mg / kg); there were different degrees of erythema and edema within 72 h after skin irritation in rabbits; mean total skin irritation score 0.5 points; rabbit eyes after conjunctival hyperemia, edema, corneal damage, symptoms disappeared after 72 h, the total value of eye irritation, the highest average of 3.5 points. Tip DNAN by acute toxicity dose classification is a moderate toxicity of the skin, eyes slightly irritating.