Based on information entropy theory, the definition of relative entropy, and the relative entropy minimum principle, this study establishes a multi-objective optimization model for a key valve opening of an urban water distribution network(WDN). Each node pressure is taken as the main research object to reduce pipeline leakage. Moreover, genetic algorithm is applied in the proposed model to solve the key valve opening of the actual WDN in a city in southern China. Using the proposed model, the relevant decision variables of a WDN can be optimized to provide a new manner of network dispatching. Based on information entropy theory, the definition of relative entropy, and the relative entropy minimum principle, this study establishes a multi-objective optimization model for a key valve opening of an urban water distribution network (WDN). Each node pressure is taken as the the main research object to reduce pipeline leakage. Moreover, genetic algorithm is applied in the proposed model to solve the key valve opening of the actual WDN in a city in southern China. Using the proposed model, the relevant decision variables of a WDN can be optimized to provide a new manner of network dispatching.