该文报导了发生家族性自发性气胸(FSP)的23人家族,有6人患该病。过去文献未报导过本病有遗传标志,因此需进一步作血清学测定α_1抗胰蛋白酶(AAT)表型、人类白细胞抗原(HLA)分型和肺组织病理学等检查,以确定本病的共同特征。调查了该家族23名成员的现在史、过去史和职业病史。检测了 AAT、糖蛋白、与 AAT 缺乏可能有关的肝胆异常,以及蛋白酶抑制剂(Pi)表 The article reports a 23-person family with familial spontaneous pneumothorax (FSP), in which 6 people develop the disease. In the past the literature did not report the genetic markers of this disease, so the need for further serological determination of α_1 antitrypsin (AAT) phenotype, human leukocyte antigen (HLA) typing and lung histopathology and other tests to determine the common disease feature. The present, past and occupational medical history of the 23 members of this family were investigated. AAT, glycoproteins, hepatobiliary abnormalities that may be associated with AAT deficiency, and protease inhibitor (Pi) tables were examined