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目的了解高胆红素血症新生儿巨细胞病毒(HCMV)感染情况并分析其意义。方法对170例高胆红素血症新生儿血清标本检测抗HCMV-IgG和IgM及血清总胆红素(TBIL),以排除高胆红素血症新生儿(100例)血清为正常对照;对筛查HCMV-IgM阳性的标本进一步分析DNA含量。结果高胆红素血症患者血清HCMV-IgG、IgM阳性率分别为57.6%和13.5%,正常对照组为42.0%和3.0%,差异均有统计学意义(P<均0.05);单个核细胞DNA阳性率86.9%,血浆游离DNA阳性率13%,差异有统计学意义。结论 HCMV感染与新生儿高胆红素血症相关性大,可能是引起高胆红素血症的主要病原之一;且HCMV DNA主要分布于单个核细胞中。
Objective To understand the status of neonatal cytomegalovirus (HCMV) infection in hyperbilirubinemia and analyze its significance. Methods Serum samples from 170 neonates with hyperbilirubinemia were tested for anti-HCMV-IgG and IgM and serum total bilirubin (TBIL) to exclude hyperbilirubinemia (100 cases) serum as normal control; DNA samples were further analyzed for specimens that were positive for HCMV-IgM screening. Results The positive rates of serum HCMV-IgG and IgM in patients with hyperbilirubinemia were 57.6% and 13.5%, respectively, and those in the normal control group were 42.0% and 3.0%, respectively, with statistical significance (P <0.05) DNA positive rate of 86.9%, plasma free DNA positive rate of 13%, the difference was statistically significant. Conclusions HCMV infection is associated with neonatal hyperbilirubinemia and may be one of the major pathogens causing hyperbilirubinemia. HCMV DNA is mainly distributed in mononuclear cells.