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硝苯吡啶是钙通道阳滞剂中扩张血管作用最强者,临床常用于下列疾病: 变易型心绞痛:动物实验,硝苯吡啶可抑制麦角新碱所引起的血管痉挛,也可防止服用心得安的冠心病患者冷加压试验所引起的血管痉挛。硝苯吡啶抑制血管平滑肌的钙离子内流,解除冠脉痉挛,增加冠脉血流量,对变易型心绞痛有良效。发作时10mg,舌下含服,5分钟显效,为了预防发作,10mg 3次/日。必要时可加大到20mg 3次/日。若夜间发作,可于睡前加服10mg。伴存的心律失常,系心肌缺血引起,本药亦有良效。劳力型心绞痛:对劳力型心绞痛的作用机制有:①扩张体循环动脉血管,左室排血阻抗降低,
Nifedipine calcium channel blocker is the strongest in the expansion of blood vessels, clinically used in the following diseases: Variant angina: animal experiments, nifedipine can inhibit ergometrine caused by vasospasm, but also to prevent the use of propofol Of patients with coronary heart disease cold pressure test induced vasospasm. Nifedipine inhibits vascular smooth muscle calcium influx, relieve coronary artery spasm, increase coronary blood flow, has a good effect on patients with variant angina. Attack 10mg, sublingual, 5 minutes markedly effective, in order to prevent the attack, 10mg 3 times / day. If necessary, can be increased to 20mg 3 times / day. If the attack at night, before going to bed plus service 10mg. With the arrhythmia, Department of myocardial ischemia, the drug also has good effect. Labor-type angina pectoris: the mechanism of exertional angina pectoris are: ① expansion of systemic arterial blood vessels, left ventricular ejection resistance decreased,