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心律紊乱的处理,特别是控制室性心律失常,对减少和预防心脏病患者的猝死具有重要作用。过去10年中,曾有多种抗心律失常药物广泛应用于临床,如达舒平、慢心律、妥卡律及乙胺碘呋酮等。然而,由于有些药物产生耐药性或有较严重的不良反应;有些药物半寿期较短,需每日多次给药,因此继续寻找和研究安全而长效的抗心律失常药物仍非常必要。本文介绍国外研究的几种较新的抗心律失常药物以及对该药的临床评价。
The treatment of arrhythmia, especially the control of ventricular arrhythmias, plays an important role in reducing and preventing sudden cardiac death. In the past 10 years, a variety of anti-arrhythmic drugs have been widely used in clinical practice, such as dazhu ping, slow heart rhythm, warfarin and amiodarone and so on. However, it is still necessary to continue to find and study safe and long-acting anti-arrhythmic drugs because some drugs are resistant or have more serious side effects; some have shorter half-lives and need to be administered more than once daily . This article introduces several newer antiarrhythmic drugs studied abroad and the clinical evaluation of the drug.