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目的:评价促生素在治疗溃疡性结肠炎(UC)方面的效果。方法:检索近年来发表在PubMed、Medline上关于促生素治疗UC的文献,按循证医学文献质量评价标准对其进行方法学与文献质量分析。结果与结论:大多数研究均表明,促生素在UC急性期缓解及维持药物诱导缓解方面均具有积极作用。微生态制剂作为一种新型的治疗方式应用于UC的临床治疗,尚需开展一些严格设计的、随机对照试验来解决一些治疗过程可能面临的问题。
PURPOSE: To evaluate the effect of pro-biotics in the treatment of ulcerative colitis (UC). Methods: The literatures on the treatment of UC by PubMed and Medline published in PubMed and Medline in recent years were searched. The methodology and literature quality were analyzed according to the quality of evidence-based medical literature. RESULTS AND CONCLUSIONS: Most studies have shown that pro-biotics have a positive effect on the acute phase of UC and the maintenance of drug-induced remission. As a new treatment method applied to the clinical treatment of UC, microecological preparations still need to carry out some strictly designed and randomized controlled trials to solve some problems that may be encountered in the course of treatment.