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目的分析糖化血红蛋白(HbA1c)与空腹血糖(FPG)、葡萄糖耐量试验(OGTT)在妊娠糖尿病(GDM)筛查、诊断、治疗中的临床意义。方法选择2014年1月-2015年12月在医院进行产前检查的孕妇236例,其中GDM患者118例(观察组),正常孕妇118例(对照组)。对236例孕妇的HbA1c及FPG及OGTT进行检测。结果观察组患者HbA1c、FPG、OGTT中的1 h血糖和2 h血糖均显著高于对照组,差异均有统计学意义(P<0.05)。观察组患者的HbA1c、FPG及OGTT中1 h、2 h血糖阳性率均显著高于对照组,差异均有统计意义(P<0.05)。HbA1c、FPG及OGTT中1 h、2 h血糖对GDM的灵敏度、特异度、诊断准确度均较高。结论 HbA1c稳定性较好,与FPG和OGTT联合检测有利于GDM的筛查、诊断、疗效观察和预后判断。
Objective To analyze the clinical significance of glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG) and glucose tolerance test (OGTT) in the screening, diagnosis and treatment of gestational diabetes mellitus (GDM). Methods A total of 236 pregnant women were enrolled in the hospital from January 2014 to December 2015, including 118 GDM patients (observation group) and 118 normal pregnant women (control group). 236 pregnant women HbA1c and FPG and OGTT were detected. Results The levels of HbA1c, FPG and OGTT in the observation group were significantly higher than those in the control group (P <0.05). The positive rates of HbA1c, FPG and OGTT in observation group at 1 h and 2 h were significantly higher than those in control group (P <0.05). HbA1c, FPG and OGTT in 1 h, 2 h blood glucose on GDM sensitivity, specificity, diagnostic accuracy are high. Conclusion The stability of HbA1c is good. The combination of FPG and OGTT is beneficial to screening, diagnosis, curative effect and prognosis of GDM.