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目的了解内镜下覆膜支架置入对晚期食管癌患者生活质量的影响。方法采用欧洲癌症研究与治疗组织生存质量问卷第3版(EORTCQLQ-C30V3.0)和食管癌专用量表(QLO-OES18)对2004年9月至2008年10月在我院进行覆膜支架置入治疗的伴有吞咽困难的38例无法手术治疗的晚期食管癌患者在治疗前、治疗后1周、4周和12周进行生存质量评估。结果覆膜支架置入后患者整体生活质量(37.8±14.9对74.3±10.8;P<0.01)和所有功能领域生活评分显著提高并持续到治疗后12周。患者吞咽困难症状明显改善(18.9±24.5对90.8±7.9;P<0.01),并持续到治疗后12周。梗阻(48.1±27.5对18.3±30.5;P<0.01)和进食(25.2±15.7对5.1±18.7;P<0.01)等症状方面均有显著改善。结论覆膜支架置入能够显著提高患者的整体生存质量和全部功能领域评分,并能改善患者的吞咽困难和梗阻等症状。
Objective To understand the effect of endoscopic stent-graft on the quality of life of patients with advanced esophageal cancer. Methods The European Society of Cancer Research and Treatment Organization Quality of Life Questionnaire, 3rd edition (EORTCQLQ-C30V3.0) and esophageal cancer specific scale (QLO-OES18) were used in our hospital from September 2004 to October 2008 Thirty-eight patients with advanced esophageal cancer who did not undergo surgery were enrolled in the evaluation of quality of life before treatment, 1 week, 4 weeks and 12 weeks after treatment. Results The overall quality of life (37.8 ± 14.9 vs 74.3 ± 10.8; P <0.01) and the functional scores of all functional areas improved significantly after stent implantation and continued to 12 weeks after treatment. Patients with dysphagia significantly improved symptoms (18.9 ± 24.5 vs. 90.8 ± 7.9; P <0.01) and persisted to 12 weeks after treatment. Obstruction (48.1 ± 27.5 vs 18.3 ± 30.5; P <0.01) and eating (25.2 ± 15.7 versus 5.1 ± 18.7; P <0.01) were significantly improved. Conclusion The stent graft can significantly improve the overall quality of life of patients and all functional areas score, and can improve the patient’s symptoms of dysphagia and obstruction.