目的　探讨Ｏｃｔｒｅｏｔｉｄｅ 对细胞因子刺激后的人眼球后成纤维细胞的细胞间粘附分子１（ＩＣＡＭ１） 表达及ＤＮＡ 合成的影响。方法　应用细胞培养技术， 测定加入细胞因子及Ｏｃｔｒｅｏｔｉｄｅ后ＩＣＡＭ１ 表达和ＤＮＡ 合成情况。结果　ＴＮＦα（１０３ Ｕ／ｍｌ） 、γＩＮＦ（１００ Ｕ／ｍｌ） 和ＩＬ１β（１００ Ｕ／ｍｌ） 均能强烈刺激眼球后成纤维细胞表面ＩＣＡＭ１ 表达，而低浓度（ 即药理浓度）Ｏｃｔｒｅｏｔｉｄｅ 能明显地抑制这种刺激作用，但所需浓度及发挥抑制作用的时间各不相同；同样，低浓度Ｏｃｔｒｅｏｔｉｄｅ 也能抑制细胞因子（除ＩＬ１β外） 刺激的ＤＮＡ 合成。结论　Ｏｃｔｒｅｏｔｉｄｅ 治疗Ｇｒａｖｅｓ’眼病的作用途径部分是通过抑制细胞因子的作用，使ＩＣＡＭ１ 表达及ＤＮＡ 合成减少，它可能具有免疫调节的特性。 Objective To investigate the effect of Octreotide on the expression of ICAM1 and DNA synthesis in human eye fibroblasts stimulated by cytokines. Methods Cell culture techniques were used to determine ICAM1 expression and DNA synthesis after addition of cytokines and Octreotide. Results Both TNFα (100 U / ml), γINF (100 U / ml) and IL1β (100 U / ml) could strongly stimulate the expression of ICAM1 on the surface of fibroblasts. However, Pharmacological concentration) Octreotide significantly inhibited this stimulus, but the concentration required and the time to exert different effects; Similarly, low concentrations of Octreotide can inhibit cytokine (except IL  1β) stimulated DNA synthesis. Conclusions Octreotide treatment Graves’ eye pathways partly through the inhibition of cytokines, ICAM 1 expression and DNA synthesis reduced, it may have immunomodulatory properties.