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目的:探讨樱桃核挥发油的抗炎作用。方法:建立大鼠角叉菜胶足跖肿胀模型和二甲苯致小鼠耳肿胀模型以及小鼠腹腔毛细血管通透性试验,观察樱桃核挥发油的抗炎效果。结果:樱桃核挥发油均能较明显地抑制角叉菜胶引起的大鼠足跖肿胀;在致炎后1h,樱桃核挥发油高剂量(0.20mL/kg)对角叉菜胶引起的大鼠足肿胀有抑制作用(P<0.01);在致炎后2～6h,樱桃核挥发油低(0.05mL/kg)、中(0.10mL/kg)、高剂量均可较明显地抑制角叉菜胶引起的大鼠足肿胀(P<0.05,P<0.01,P<0.001)。小鼠耳肿胀度樱桃核挥发油低、中、高剂量组与模型组比较,均有较明显的抑制作用(P<0.01)。与模型组比较,樱桃核挥发油低、中、高剂量能够较明显地降低小鼠腹腔毛细血管通透性(P<0.01)。结论:樱桃核挥发油对急性炎症有抑制作用,且存在一定的量效关系。
Objective: To investigate the anti-inflammatory effect of cherry nuclear volatile oil. Methods: The carrageenan paw edema model and xylene-induced mouse eardrum swelling model and the mouse peritoneal capillary permeability test were established to observe the anti-inflammatory effect of the cherry essential oil. Results: The cherry radish oil could obviously inhibit the rat paw edema induced by carrageenan. At 1 h after proinflammation, high dose of cherry kernel volatile oil (0.20 mL / kg) induced carrageenan - induced rat foot (P <0.01). Carrageenan was significantly inhibited by low (0.05 mL / kg), medium (0.10 mL / kg) and high doses of cherry kernel volatile oil 2 ~ 6 h after inflammation Of rat foot swollen (P <0.05, P <0.01, P <0.001). Ear swelling in mice with cherry nuclear volatile oil low, medium and high dose groups compared with the model group, were significantly inhibited (P <0.01). Compared with the model group, low, medium and high doses of cherry kernel volatile oil could significantly reduce the peritoneal capillary permeability of mice (P <0.01). Conclusion: The volatile oil of cherry can inhibit the acute inflammation, and there is a certain dose-effect relationship.