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目的 比较研究UFTM和EAP化疗方案治疗晚期胃癌的疗效 ,生存时间和毒副反应。方法 5 3例晚期胃癌接受系统化疗 ,UFTM组 2 8例 ,EAP组 2 5例。结果 两组有效率 (CR +PR)分别为5 0 %和 6 0 % ,无显著性差异 (P >0 .0 5 ) ,中位生存期为 6月和 7月 ,毒副反应主要为消化道反应和骨髓抑制 ,EAP明显高于UFTM (P <0 .0 5 )。结论 两方案对晚期胃癌均有较好的疗效 ,但EAP方案毒副反应大 ,临床应用范围受到限制。
Objective To compare the efficacy, survival time and toxicity of UFTM and EAP chemotherapy for advanced gastric cancer. Methods Fifty-three patients with advanced gastric cancer received systemic chemotherapy, 28 in the UFTM group and 25 in the EAP group. Results The effective rates (CR + PR) of the two groups were 50% and 60% respectively, with no significant difference (P> 0.05). The median survival time was June and July. The toxic and side effects were mainly digestion Road response and myelosuppression, EAP was significantly higher than UFTM (P <0.05). Conclusion Both plans have good curative effect on advanced gastric cancer, but the side effects of EAP are large and the clinical application is limited.