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目的:旨在通过对攻毒杀虫止痒类中药饮片安全事件报道的系统梳理,分析其发生不良反应/事件(ADR/ADE)的特点及原因,提出攻毒杀虫止痒类中药饮片的警戒与合理用药建议。方法:系统检索30年来国内外文献,收集和整理11味攻毒杀虫止痒类中药饮片的ADR/ADE文献,采用文献回顾研究和统计学方法对该类中药饮片的不良反应情况进行分析。结果:收集攻毒杀虫止痒类中药饮片ADR/ADE文献报道152篇,最终纳入75篇,案例121例。涉及ADR/ADE的中药饮片共9味,占攻毒杀虫止痒类饮片数的81.82%。该类饮片主要表现为消化系统损害,引起ADR/ADE的主要因素有过量使用、患者自行用药及机体因素等。结论:攻毒杀虫止痒类中药饮片发生安全事件多见于雄黄。加强攻毒杀虫止痒类中药饮片的用药警戒,对提高该类饮片的安全合理应用具有重要意义。
OBJECTIVE: To analyze the characteristics and causes of adverse reactions / events (ADR / ADE) by analyzing systematically the safety incidents of insecticidal and antipruritic TCM Pieces, Caution and rational drug advice. Methods: The literature of ADR / ADE was collected systematically and systematically for 30 years. The literature of ADR / ADE was collected and sequenced. The adverse reactions of this kind of Chinese herbal medicine were analyzed by literature review and statistical methods. Results: 152 cases of ADR / ADE were collected and reported in the literature, with 75 cases eventually being included and 121 cases in 121 cases. A total of 9 Chinese Herbal Pieces involving ADR / ADE, accounting for 81.82% of the number of anti-inflammatory insecticidal itching class Pieces. Such Pieces mainly for the digestive system damage caused by ADR / ADE overuse of the main factors, the patient’s own medication and the body factors. Conclusion: It is more common in realgar to find out the safety incidents of poisoning and anti-itch type Chinese Herbal Pieces. Strengthen the attack insecticide anti-itch class medicine Herbal Pieces alert, to improve the safe and rational use of such Pieces is of great significance.