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目的对酮症起病的T2DM患者的临床特征进行分析,探讨酮症倾向的T2DM的发病机制。方法收集新诊断的T2DM患者167例,其中以酮症起病T2DM患者(KPD组)76例,无酮症的T2DM者(T2DM组)91例,比较两组治疗前的BMI、随机血糖、TG、HbA1c、FC-P、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)。结果 KPD组超重及肥胖患者比例、随机血糖、HbA1c、TG水平、HOMA-IR均高于T2DM组(P<0.005或P<0.001),FC-P水平、HOMA-β指数低于T2DM组(P<0.001)。但治疗后两组FC-P水平,比较差异无统计学意义。结论酮症倾向的T2DM发病原因可能与更高水平的随机血糖、TG、肥胖及与之伴随的慢性炎症有关。
Objective To analyze the clinical features of T2DM patients with ketosis onset and explore the pathogenesis of ketosis-prone T2DM. Methods A total of 167 newly diagnosed T2DM patients were collected, including 76 KTD patients (KPD group) and 91 diabetic T2DM patients (T2DM group). The BMI before treatment, random blood glucose, TG , HbA1c, FC-P, HOMA-β, HOMA-IR. Results The proportion of patients with overweight and obesity in KPD group were significantly higher than those in T2DM group (P <0.005 or P <0.001). The levels of HbA1c, TG, HOMA-IR and HOMA- <0.001). However, there was no significant difference in FC-P levels between the two groups after treatment. Conclusions The pathogenesis of ketosis-prone T2DM may be related to higher levels of randomized blood glucose, TG, obesity and the accompanying chronic inflammation.