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目的 :比较老年与青年人的股骨头骨质密度、酶和细胞因子 ,进而探讨老年骨丢失的发生机理。方法 :取新鲜性老年股骨颈骨折的股骨头和正常青年股骨头 ,进行骨矿含量、碱性磷酸酶、白细胞介素 -6、肿瘤坏死因子和组织形态计量检测。结果 :老年组股骨头骨矿含量明显低于青年组 (P <0 0 1) ,老年组肿瘤坏死因子含量显著高于青年组 (P <0 0 1)。肿瘤坏死因子与骨矿含量呈显著的负相关 (r =-0 743 ,P <0 0 1)。结论 :骨质疏松的发生与骨骼局部肿瘤坏死因子的升高有关。
OBJECTIVE: To compare femoral head bone density, enzymes and cytokines in elderly and young people and to explore the mechanism of senile bone loss. Methods: Femoral head and normal femoral head of fresh femoral neck fractures were taken for measurement of bone mineral content, alkaline phosphatase, interleukin-6, tumor necrosis factor and histomorphometry. Results: The content of femoral bone mineral in aged group was significantly lower than that in young group (P <0.01). The content of tumor necrosis factor in elderly group was significantly higher than that in young group (P <0.01). Tumor necrosis factor had a significant negative correlation with bone mineral content (r = -0 743, P <0.01). Conclusion: The incidence of osteoporosis is related to the increase of local tumor necrosis factor.