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Dear Editor,rnMitochondrial Ca2+ homeostasis regulates energy production, cell division, and cell death.The basic properties of mitochondrial Ca2+ uptake have been firmly established.The Ca2+ influx is mediated by MCU, driven by membrane potential and using a uniporter mechanism (Vasington and Murphy, 1962).Patch-clamp analysis of MCU currents demonstrated that MCU is a channel with exceptionally high Ca2+ selectivity (Kirichok et al., 2004).