单用全反式维甲酸（ATRA）治疗急性早幼粒细胞白血病（APL）23例诱导达完全缓解（CR）后，采用ATRA与联合化疗交替的方法维持治疗。18例随访一年以上，生存率83．4％。用上述维持治疗者一旦复发，患者对多种药物呈抗药性，复发后的治疗较困难，多数于1个月内死亡。采用此方法维持治疗是否较及早停用ATRA，单用强烈化疗维持治疗优越，尚待进一步观察、研究。 Twenty-three cases of acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA) for complete remission (CR). ATRA and combination chemotherapy were used to maintain the therapy. 18 cases were followed up for more than a year, the survival rate was 83.4%. With the recurrence of maintenance treatment of patients, the patient was resistant to a variety of drugs, the treatment of relapsed more difficult, most died within 1 month. Adopting this method to maintain the treatment is faster than using ATRA, the treatment of severe chemotherapy alone is superior, pending further observation and study.