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目的 探讨肾移植术后延迟应用环孢素A(CsA)并结合预防性使用抗人淋巴细胞球蛋白(ALG)的四联免疫抑制剂顺序用药对移植肾早期功能的影响。方法 观察并比较90例延迟应用CsA的四联顺序用药(实验组)和215例肾移植术后立即应用CsA(对照组)的近期疗效。结果 实验组移植肾功能恢复快(P<0.01),急性肾小管坏死(ATN)发生率明显降低(P<0.01);两组急性排斥及巨细胞病毒感染发生率均无显著性差异(P>0.05)。结论 肾移植术后延迟应用CsA并结合预防性应用ALG是一种理想的用药方案。
Objective To investigate the effects of sequential administration of cyclosporin A (CsA) combined with prophylactic anti-human lymphocyte globulin (ALG) quadruple immunosuppressant on the early function of renal allografts after renal transplantation. Methods 90 cases of delayed sequential CsA (experimental group) and 215 cases of immediate effect of CsA (control group) after renal transplantation were observed and compared. Results The renal function recovery of the experimental group was faster (P <0.01) and the incidence of acute tubular necrosis (ATN) was significantly lower (P <0.01). There was no significant difference between the two groups in the incidence of acute rejection and cytomegalovirus infection (P> 0.05). Conclusion The delayed application of CsA after renal transplantation combined with prophylactic use of ALG is an ideal drug regimen.