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为了合成15-甲基前列腺素F_(2α),需要合成3-甲基-3-烯丙氧基-辛炔-1(1).采用醇钠与烯丙基卤反应的合成方法,我们将化合物2在四氢呋喃溶液中与氢化钠作用生成钠盐,然后在回流时滴加烯丙溴,但没有获得预期的结果.所得的主要产物,经红外光谱测定表明不含炔基,而存在酮基和双键;核磁共振谱出现特征的—CH_2CH=CH_2一组峰,在δ为1.94有一个甲基单峰;质谱分析,分子量为154,存在特征的甲基酮的碎片峰
For the synthesis of 15-methyl prostaglandin F 2α, it is necessary to synthesize 3-methyl-3-allyloxy-octyne-1 (1) .According to the synthetic method of reacting sodium alcoholate with allyl halide, Compound 2 was reacted with sodium hydride in tetrahydrofuran to form the sodium salt and then allyl bromide was added dropwise at reflux, but the desired result was not obtained.The main product obtained, as determined by infrared spectroscopy, was free of alkynyl groups and present in the ketone group And double bonds; a group of -CH 2 CH═CH 2 peaks characteristic of the nuclear magnetic resonance spectrum showing a single peak at δ of 1.94; MS analysis of a molecular weight of 154 showing the characteristic fragment of methylketone