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目的:观察至灵胶囊与抑平舒、尿激酶合用治疗原发性局灶节段性肾小球硬化性肾炎的疗效。方法:随机选择30例局灶节段性肾小球硬化性肾炎患者,给予至灵胶囊4粒,每日3次;抑平舒2.5mg,每日1次;尿激酶15万单位,每日1次静滴。疗程4周。观察治疗前后24小时尿蛋白定量、血肌酐水平。结果:治疗后24小时尿蛋白定量由治疗前的3.05±3.28g降低到1.96±2.44g(P<0.01);血肌酐为85.41±2.69μmol/L,与治疗前(84.12±3.56μmol/L)比较,无显著性差异(P>0.05)。结论:至灵胶囊与抑平舒、尿激酶合用治疗以中等量尿蛋白为主的局灶节段性肾小球硬化性肾炎,可明显降低尿蛋白,这是对治疗局灶节段性肾小球硬化性肾炎的一种尝试,提示中西医治疗前景广阔。
Objective: To observe the effect of Zhiling Capsule, Yuping Shu and Urokinase in the treatment of primary focal segmental glomerulosclerosis nephritis. Methods: Thirty patients with focal segmental glomerulosclerosis nephritis were randomly selected and treated with 4 capsules of Ling Capsule, 3 times a day. Pills 2.5 mg, once a day, 150,000 units of urokinase 1 intravenous infusion. Treatment for 4 weeks. 24 hours before and after treatment to observe urinary protein, serum creatinine levels. Results: Urinary protein quantitation at 24 hours after treatment decreased from 3.05 ± 3.28g before treatment to 1.96 ± 2.44g (P <0.01), while serum creatinine was 85.41 ± 2.69μmol / L before treatment (84.12 ± 3.56μmol / L) No significant difference (P> 0.05). Conclusion: The combination of Zhiling Capsule and Ping Shu Shu, urokinase in the treatment of focal segmental glomerulosclerosis nephritis with moderate amount of urinary protein can significantly reduce urinary protein, which is the treatment of focal segmental renal An attempt to glomerulonephritis, prompted the broad prospects for the treatment of Chinese and Western medicine.