论文部分内容阅读
目的 从海洋蓝细菌Okeania hirsuta中分离鉴定次级代谢产物并进行细胞毒活性评价.方法 3个天然产物(1～3)的结构确定是通过广泛的波谱数据,包括一维和二维核磁及质谱等.结果 化合物3对人体肺癌细胞NCI-H460显示出强的细胞毒活性,IC50值为0.384 μg/mL.结论 这是首次从Okeania属蓝细菌中分离获得化合物1～3.这些天然产物的发现表明Okeania属蓝细菌可以作为发现新颖化合物的重要来源.“,”Objective To study the secondary metabolites of the marine cyanobacterium Okeania hirsuta and their cytotoxic activity.Methods The structures of the isolated three natural compounds (1 ～ 3) were identified by comprehensive spectroscopic data including 1H NMR,13C NMR,2D NMR and ESIMS.Results Compound 3 showed strong cytotoxic activity against human lung tumor cell line NCI-H460 with an IC50 value of 0.384 μg/mL.Conclusion This is the first time to isolate these compounds from cyanobacteria of the genus Okeania.The discovery of these natural products suggests that the cyanobacterial genus Okeania would be a significant resource of structurally interesting molecules in the future.