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目的确定毫米波导致胚胎损伤阈值及仔鼠学习记忆功能降低的机理。方法用３７４、４２．２、５３．０和６０．０ＧＨｚ，功率密度１～８ｍＷ／ｃｍ２毫米波，在小鼠怀孕６～１５天时每天进行２小时辐射，用电迷宫对仔鼠进行学习记忆功能测试，用受体放射配基分析、高效液相色谱电化学检测和放射免疫法对仔鼠脑Ｍ胆碱能受体、单胺递质和精氨酸加压素（ＡＶＰ）进行测定。结果３７．４、４２．２ＧＨｚ和５３．０、６０．０ＧＨｚ毫米波导致仔鼠学习记忆功能降低、海马区最大受体结合数增加、脑多巴胺（ＤＡ）下降的最小功率密度分别为５和３ｍＷ／ｃｍ２，导致成年子鼠下丘脑内ＡＶＰ降低的最小功率密度分别为８和５ｍＷ／ｃｍ２。随功率密度增加，辐射导致胎仔损伤程度加重。毫米波未使孕鼠体温升高。结论３７．４、４２．２ＧＨｚ和５３．０、６０．０ＧＨｚ毫米波导致胚胎损伤阈值分别为３～５ｍＷ／ｃｍ２和１～３ｍＷ／ｃｍ２，其导致仔鼠学习记忆功能降低与其脑中ＡＶＰ、ＤＡ含量下降及海马区胆碱能神经活性降低相关，此效应由毫米波非热效应所致，未见毫米波的频率特异性
OBJECTIVE: To determine the threshold of embryonic damage induced by millimeter wave and the mechanism of learning and memory abilities in pups. Methods 37.4, 42.2, 53.0 and 60.0 GHz, power density 1 ~ 8mW / cm2 millimeter wave were used to irradiate mice for 2 hours everyday from 6 to 15 days of pregnancy, Memory function test, receptor radioligand analysis, high performance liquid chromatography-electrochemical detection and radioimmunoassay on the offspring brain M cholinergic receptors, monoamine neurotransmitters and arginine vasopressin (AVP) Measurement was performed. Results At 37.4,42.2GHz and 53.0,60.0GHz millimeter wave, the learning and memory abilities of the offspring were decreased, the maximum number of receptor binding in the hippocampus was increased, and the minimum power densities of brain dopamine (DA) were 5 and 3 mW / Cm2, causing the minimum power density of AVP reduction in the hypothalamus of adult offspring to be 8 and 5 mW / cm2, respectively. As the power density increases, the radiation causes a greater degree of fetal injury. Millimeter wave pregnant mice did not increase body temperature. Conclusion The embryonic damage thresholds of 37.4,42.2GHz and 53.0,60.0GHz were 3 ~ 5mW / cm2 and 1 ~ 3mW / cm2 respectively, which led to the decrease of learning and memory abilities and the changes of AVP, DA Decreased content and decreased cholinergic activity in the hippocampus, this effect is caused by the non-thermal effects of millimeter-wave, no frequency-specific millimeter-wave