【摘 要】
：
Despite considerable progresses in cancer treatment,tumor metastasis is still a thorny issue,which leads to majority of cancer-related deaths.In hematogenous metastasis,the concept of“seed and soil”suggests that the crosstalk between cancer cells(seeds)an
【机 构】
：
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry,Sichuan Engineer
论文部分内容阅读
Despite considerable progresses in cancer treatment,tumor metastasis is still a thorny issue,which leads to majority of cancer-related deaths.In hematogenous metastasis,the concept of“seed and soil”suggests that the crosstalk between cancer cells(seeds)and premetastatic niche(soil)facilitates tumor metastasis.Considerable efforts have been dedicated to inhibit the tumor metastatic cascade,which is a highly complicated process involving various pathways and biological events.Nonetheless,satisfactory therapeutic outcomes are rarely observed,since it is a great challenge to thwart this multi-phase process.Recent advances in nanotechnology-based drug delivery systems have shown great potential in the field of anti-metastasis,especially compared with conventional treatment methods,which are limited by serious side effects and poor efficacy.In this review,we summarized various factors involved in each phase of the metastatic cascade ranging from the metastasis initiation to colonization.Then we reviewed current approaches of targeting these factors to stifle the metastatic cascade,including modulating primary tumor microenvironment,targeting circulating tumor cells,regu-lating premetastatic niche and eliminating established metastasis.Additionally,we highlighted the multi-phase targeted drug delivery systems,which hold a better chance to inhibit metastasis.Besides,we demonstrated the limitation and future perspectives of nanomedicine-based anti-metastasis strategies.
其他文献
ω-Conotoxins inhibit N-type voltage-gated calcium(Cav2.2)channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index.Here,we synthesized and characterized a novel ω-conotoxin,Bu8 from Conus bullatus,which consists of 25
Rheumatoid arthritis(RA)is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes(FLS).The up-regulated cellular membrane expres-sion of G protein coupled receptor kinase 2(GRK2)of FLS plays a critical
Lung cancers are the leading cause of cancer deaths worldwide and pose a grave threat to human life and health.Non-small cell lung cancer(NSCLC)is the most frequent malignancy occupying 80％of all lung cancer subtypes.Except for other mutations(e.g.,KRASG1
Many sensitizers have not only photodynamic effects,but also sonodynamic effects.Therefore,the combination of sonodynamic therapy(SDT)and photodynamic therapy(PDT)using sensitizers for sono-photodynamic therapy(SPDT)provides alternative opportunities for
Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells.Mitochondrial dynamics balance is exactly regu-lated by molecular motor consisted of myosin and actin cytoskeleton
Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases.A natural fragment of serum albumin,named EPI-X4,has previously been identified as endogenous peptide antagonist and inverse agonist
Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol(PPD)-,protopanaxatriol(PPT)-,ocotillol(OCT)-and oleanane(OA)-type saponins known as active compounds of Panax genus.They are accumulated in plant roots,stems,leaves,an
Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies.Immune cell modulation through the admin-istration of drugs,proteins,and cells can enhance antitumor
Blood-brain barrier(BBB)damage after ischemia significantly influences stroke outcome.Com-pound LFHP-1c was previously discovered with neuroprotective role in stroke model,but its mechanism of action on protection of BBB disruption after stroke remains un
Protein arginine methyltransferases(PRMTs)have been implicated in the progression of many diseases.Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery.