新生儿缺氧缺血性脑病 (hypoxicischemicen cephalopathy ,HIE)是围生期最主要的神经系统疾病 ,病死率高。近年来随着诊断、治疗水平的提高 ,该病的发病率和病死率明显降低。以往临床上的诊断 ,主要依靠临床表现和影像学检查 ,而有关血液生物学改变的报道较少。本文就HIE病儿的 Hypoxic ischemic encephalopathy (HIE) is the most important perinatal neurological disease, high mortality. In recent years, with the diagnosis and treatment to improve the incidence and mortality significantly reduced. In the past clinical diagnosis, mainly rely on clinical manifestations and imaging studies, and less reports on changes in blood biology. This article HIE sick children