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目的:评价人乳头瘤病毒(HPV)分型测定在宫颈上皮内瘤变(CIN)等宫颈癌前病变筛查中的应用价值。方法:利用PCR-流式荧光杂交法对319例可疑患者进行26种HPV基因亚型检测(含19种高危亚型和7种低危亚型)。结果:HPV检出率为17.9%(57/319),其中高、低危型检出率分别为16.9%(54/319)与4.4%(14/319),高危型中主要为HPV16、18、523、3感染,低危型主要为HPV61、1感染。尖锐湿疣、宫颈上皮内瘤变(CIN)与正常对照组比较检出率差别有统计学意义(P<0.05)。结论:HPV16、185、23、31、1、6是本地区HPV感染的主要型别,20岁～40岁为女性感染的高峰人群,对阳性患者定期跟踪,是防治宫颈上皮内瘤变(CIN)与宫颈癌的有效途径。
Objective: To evaluate the value of HPV typing in cervical intraepithelial neoplasia (CIN) and other precancerous lesions screening. Methods: Twenty-six HPV genotypes were detected in 319 suspicious patients (including 19 high-risk subtypes and 7 low-risk subtypes) by PCR-flow fluorescent hybridization. Results: The detection rate of HPV was 17.9% (57/319). The detection rates of high and low risk type were 16.9% (54/319) and 4.4% (14/319) respectively. The high risk type was HPV16,18 , 523,3 infection, low-risk type HPV61,1 infection. Condyloma acuminata, cervical intraepithelial neoplasia (CIN) compared with the control group, the difference was statistically significant (P <0.05). Conclusions: HPV16,185,23,31,1,6 is the main type of HPV infection in the region. The peak age of women infected from 20 to 40 years of age is regularly followed up by positive patients. It is the control of cervical intraepithelial neoplasia (CIN ) And cervical cancer effective way.