目的总结全胃切除术后P形空肠袢空肠食管Roux-en-Y吻合术重建消化道的临床效果。方法回顾性分析并比较全胃切除行P形空肠袢空肠食管Roux-en-Y吻合术(A组,32例)和食管空肠Roux-en-Y吻合术(B组,29例)重建消化道的临床资料。结果两组患者均获随访6个月,无吻合口出血、吻合口瘘或死亡病例。A组手术时间和术中出血量稍高于B组(P>0.05)。与术前和B组比较,A组术后体重显著增加,血红蛋白、白蛋白、总蛋白量均显著上升(P<0.05)。A组术后并发症(倾倒综合征和反流性食管炎)发生率低于B组(28.1%vs.86.2%)(P<0.05)。结论 P形空肠袢空肠食管Roux-en-Y吻合术是胃癌全胃切除术后行消化道重建的一种理想术式。 Objective To summarize the clinical effect of Roux-en-Y anastomosis of P-jejunum and esophageal reconstruction of the digestive tract after total gastrectomy. Methods The gastrointestinal tract was reconstructed by Roux-en-Y anastomosis of P-jejunum and esophageal Roux-en-Y anastomosis (group B, n = 32) The clinical data. Results Both groups were followed up for 6 months without anastomotic bleeding, anastomotic leakage or death. The operation time and blood loss in group A were slightly higher than those in group B (P> 0.05). Compared with preoperative group and B group, the postoperative body weight of group A increased significantly, and the levels of hemoglobin, albumin and total protein increased significantly (P <0.05). The incidence of postoperative complications (dumping syndrome and reflux esophagitis) in group A was lower than that in group B (28.1% vs.86.2%, P <0.05). Conclusion Roux-en-Y anastomosis of jejunum and jejunum of the P-type jejunum is an ideal method for reconstructing the digestive tract after total gastrectomy of gastric cancer.