论文部分内容阅读
【目的】评价口服塞克硝唑片治疗滴虫阴道炎的有效性和安全性。【方法】采用多中心、随机双盲、平行对照设计,入选滴虫阴道炎患者144例,塞克硝唑片组与替硝唑片组各72例,对其临床疗效和滴虫清除率进行比较,并观察用药后不良事件和实验室检查异常的发生情况。【结果】用药后塞克硝唑片组痊愈率和有效率分别为61%和94%;替硝唑片组痊愈率和有效率分别为51%和94%,两组之间比较差异无统计学意义(P>0.05)。塞克硝唑片组滴虫清除率为96%;替硝唑片组滴虫清除率为97%,两组比较差异无统计学意义(P>0.05)。144例病例中无不良事件与严重不良事件发生;塞克硝唑片组实验室检查异常发生率为0,替硝唑片组实验室检查异常发生率为4%,两组之间比较差异无统计学意义(P>0.05)。【结论】口服塞克硝唑片治疗滴虫阴道炎安全、有效。
【Objective】 To evaluate the efficacy and safety of oral Secnidazole tablets in the treatment of Trichomonas vaginalis. 【Methods】 A total of 144 patients with Trichomonas vaginitis were enrolled in the study. The clinical efficacy and trichomonad clearance rate were determined by multicentre, randomized, double-blind and parallel-controlled design. Comparison and observation of adverse events and laboratory tests after the occurrence of abnormalities. 【Results】 The cure rate and effective rate of selecidazole tablets group were 61% and 94%, respectively. The cure rate and effective rate of tinidazole tablets group were 51% and 94% respectively, there was no statistical difference between the two groups Significance (P> 0.05). Trimethoprim tablets group trichomonad clearance rate was 96%; tinidazole tablets group trichomonad clearance rate was 97%, the difference between the two groups was not statistically significant (P> 0.05). There were no adverse events and serious adverse events in 144 cases. The incidence of laboratory abnormalities in seclnidazole tablets group was 0, and the incidence of laboratory abnormalities in tinidazole tablets group was 4%. There was no significant difference between the two groups Statistical significance (P> 0.05). 【Conclusion】 Oral Secnidazole tablets are safe and effective in the treatment of Trichomonas vaginitis.