四、对恶性肿瘤的应用在Stranders的成骨肉瘤研究中,他观察了干扰素对复发的影响。而我们则从另一方面来观察干扰素对于缩小一种可测量肿瘤的效果。由于动物的淋巴瘤用干扰素治疗有效,我们选择了淋巴瘤作为研究对象。B细胞,即与淋巴瘤恶性细胞相对应的正常细胞,也是干扰素在免疫系统中能发生影响的细胞。另外,在斯丹福,我们能选择到一些易于测量肿瘤大小而又在观察期间不需要作其他治疗的淋巴瘤病例。我们首先致力于研究那些迅速增大而又对所有其他疗法皆不见效的病例,即恶性组织细胞性淋巴瘤患者。我们治疗的第一例,治疗前肿瘤迅速增大,在用 Fourth, the application of cancer In Stranders Osteosarcoma study, he observed the impact of interferon on the recurrence. On the other hand, we observe the effect of interferon on reducing a measurable tumor. As animal lymphoma is treated effectively with interferon, we chose lymphoma as the study object. B cells, that is, normal cells corresponding to lymphoma malignant cells, are also cells in which the interferon can affect the immune system. In addition, at Stanford, we were able to select among the several cases of lymphoma that were easy to measure tumor size and did not require other treatments during the observation period. We first focused on those cases of malignant histiocytic lymphomas that grew rapidly and did not work for any of the other therapies. The first case of our treatment, tumor rapidly increased before use