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目的 探讨妊娠高血压综合征 (妊高征 )患者血浆同型半胱氨酸 (HCY)与 5 -羟色胺 ( 5 -HT)含量的关系。方法 采用高效液相色谱法及荧光分光光度法测定 15例非孕妇女、2 5例正常晚孕妇女及 45例妊高征患者 (轻、中、重度各 15例 )血浆HCY和 5 -HT的含量。结果 正常晚孕妇女组血浆HCY和 5 -HT的含量高于正常非孕妇女组 ,差异有显著性 (P <0 0 5 ) ;妊高征患者组血浆HCY和 5 -HT含量与正常晚孕妇女组比较差异有显著性 (P <0 0 5 ,P <0 0 1) ;轻、中、重度妊高征患者组血浆HCY和 5 -HT含量比较差异有显著性 (P <0 0 1)。均与疾病的严重程度呈正相关。妊高征患者组血浆HCY与 5 -HT含量呈正相关 (r =0 40 7,P <0 0 5 )。结论 妊高征患者血浆HCY升高损伤血管内皮细胞 ,引起血浆 5 -HT升高 ,与妊高征的发病机制密切相关。
Objective To investigate the relationship between plasma homocysteine (HCY) and 5-hydroxytryptamine (5-HT) in patients with pregnancy induced hypertension (PIH). Methods High-performance liquid chromatography (HPLC) and fluorescence spectrophotometry were used to determine the plasma concentrations of HCY and 5-HT in 15 non-pregnant women, 25 normal pregnant women and 45 PIH patients (15 mild, moderate and severe) content. Results The levels of plasma HCY and 5 -HT in normal pregnant women were significantly higher than those in normal non-pregnant women (P <0.05). The levels of HCY and 5-HT in pregnant women with PIH were significantly lower than those in normal pregnant women There was significant difference between the female group and the control group (P <0 05, P 0 01). There was significant difference of plasma HCY and 5 -HT between the mild, moderate and severe PIH patients (P 0 01) . Both were positively correlated with the severity of the disease. There was a positive correlation between plasma HCY and 5-HT in patients with PIH (r = 0 40 7, P 0 05). Conclusions Elevated HCY in patients with PIH damages vascular endothelial cells and causes a rise in plasma 5 -HT, which is closely related to the pathogenesis of PIH.