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IFN-α治疗慢性丙型肝炎只是相对地有效,因为它对相当大部分的病人并不长期有效。本研究目的为评估在西西里确定与HCV有关的慢性肝病对IFN治疗反应中HCV病毒血症、基因型及肝组织学的相对作用。 病人与方法:100例慢性肝病患者,血清抗HCV抗体及HCV RNA均阳性,其中73例为慢性肝炎(13例轻度活动、23例中度活动、37例重度活动)及27例肝硬化,均经肝活检证实属代偿期。血清HBsAg、抗HIV及非器官特异性自身抗体均阴性。病人至少六个月ALT持续超过正常上限两倍。均无输血、药瘾或酗酒(>
IFN-α is only relatively effective in the treatment of chronic hepatitis C because it is not effective in the long term in a significant proportion of patients. The purpose of this study was to evaluate the relative role of HCV-related chronic liver disease in HCV treatment of HCV viremia, genotype and liver histology in IFN treatment in Sicily. Patients and Methods: Serum anti-HCV antibodies and HCV RNA were positive in 100 patients with chronic liver disease, of which 73 were chronic hepatitis (13 mild, 23 moderate, 37 severe) and 27 cirrhosis, Confirmed by liver biopsy is compensatory. Serum HBsAg, anti-HIV and non-organ specific autoantibodies were negative. Patients with ALT over at least six months continued to exceed the upper limit of normal twice. No blood transfusion, drug addiction or alcoholism (>