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促血管生成素 (angiopoietin,Ang)是一族分泌性蛋白因子 ,作用于内皮特异受体酪氨酸激酶 Tie- 2 ,影响内皮的增殖、迁移及管状结构形成 ,在胚胎期血管发生及成年机体的生理、病理性血管新生中发挥重要作用。Ang及其受体在肿瘤组织表达明显高于周围正常组织 ,特别是 Ang- 2 ,特异表达于肿瘤边缘的血管重建区 ,参与肿瘤血管新生的起始及延续过程 ,影响肿瘤生长和转移 ,并有望成为一种新的抗肿瘤血管新生靶向因子。
Angiopoietin (Ang) is a family of secreted protein factors that act on the endothelial-specific receptor tyrosine kinase Tie-2, affecting endothelial proliferation, migration and tubular structure formation. During angiogenesis and adult Physiological, pathological angiogenesis plays an important role. The expression of Ang and its receptor in the tumor tissue was significantly higher than that of the surrounding normal tissues, especially Ang-2, which was specifically expressed in the revascularization region of the tumor margin, involved in the initiation and continuation of tumor angiogenesis, and affected the tumor growth and metastasis Is expected to become a new anti-tumor angiogenesis targeting factor.