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目的 :分析慢性肾功能衰竭 (CRF)患者血中甲状旁腺激素 (PTH)和甲状旁腺激素相关蛋白 (PTHrP)水平的变化。方法 :采用放免法测定 92例CRF患者和 30例正常人血清PTH和血浆PTHrP含量 ,并按CRF分期 ,将CRF患者分为四期。结果 :在慢性肾功能衰竭各个阶段 ,血清PTH、血浆PTHrP含量较正常对照组明显升高 (P <0 .0 1 )。结论 :血清PTH含量及血浆PTHrP均可反映慢性肾功能衰竭的程度 ,其含量随肾功能损害的加重而逐渐升高。血清PTH含量及血浆PTHrP反映肾功能损伤基本一致。
Objective: To analyze the changes of parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) levels in patients with chronic renal failure (CRF). Methods: The levels of serum PTH and plasma PTHrP in 92 patients with CRF and 30 normal controls were determined by radioimmunoassay. CRF patients were divided into four groups according to CRF stage. Results: The levels of serum PTH and plasma PTHrP in chronic renal failure were significantly higher than those in normal control group (P <0.01). Conclusions: Serum PTH levels and plasma PTHrP can reflect the degree of chronic renal failure, its content increased with the increase of renal dysfunction and gradually increased. Serum PTH levels and plasma PTHrP reflect basically the same renal damage.