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目的：研究间接门静脉灌注５－Ｆｕ的药代动力学变化的实验方法。材料与方法： ３０只家兔分两组，分别经脾动脉和肠系膜上动脉灌注５－Ｆｕ，门静脉置管采血。实验方法包括脾动脉、肠系膜上动脉穿刺注药术和门静脉置管采血术两部分。结果：本组麻醉意外占３．３％，套管脱出占６．７％，术后１日内死亡占６．７％，３日内死亡占１０％，３日后恢复进食进水占７３．３％。总成功率达９０％。结论：本法操作简单、安全、创伤较轻，为经脾动脉、肠系膜上动脉局部给药治疗消化系肿瘤的基础研究提供了可参考的方法。
Objective: To study the experimental method of pharmacokinetics changes of indirect portal vein infusion of 5-Fu. Materials and Methods: Thirty rabbits were divided into two groups. 5-Fu was perfused through the splenic artery and superior mesenteric artery, and blood was collected from the portal vein. Experimental methods include the splenic artery, superior mesenteric artery puncture and portal vein blood sampling. Results: The anesthetic accident accounted for 3.3% in this group, and the rate of cannulation was 6.7%. The death occurred within 6.7% within one day after surgery. The death accounted for 10% within 3 days. The food intake after 3 days was 73.3%. . The total success rate is 90%. Conclusion: This method is simple, safe, and less traumatic. It provides a reference method for basic research on the treatment of digestive tumors by local administration of splenic artery and superior mesenteric artery.