以对苯二酚为原料经羟基的甲基化、傅克酰基化、肟化、肟基还原、酮胺氢化5步反应合成了盐酸甲氧明,中间体和目标产物经核磁共振氢谱、红外光谱及元素分析仪确证了其化学结构,总收率为37.6%.与传统盐酸甲氧明工艺相比,该工艺反应条件温和、简便、经济、产率高及对环境友好. Hydroxylamine hydrochloride was synthesized by 5-step reaction of methylation of hydroxyl, Friedel-Crafts, oximation, oxime group reduction and ketoamine. The intermediate and the target product were identified by 1H-NMR, The chemical structure was confirmed by IR and elemental analyzer, the total yield was 37.6% .Compared with the traditional methionine hydrochloride process, the reaction conditions were mild, simple, economical, high yield and environment friendly.