作者报道1例三环抗抑郁剂所致的恶性症状群。女性,58岁,50年代患者因长期持续抑郁而行电抽搐治疗。本次入院前7个月,在晚上始服去甲丙咪嗪50mg,治疗早期即加量至100mg/日,后因出现激动及非特征性运动障碍而减量为晚上服50mg至入院时。入院前3天,出现激越、焦虑、精神错乱、轻度震颤、频繁颊舌运动。体检:肌张力正常,无局灶性神经系统阳性体征,实验室检查发现去甲丙咪嗪浓度111ng/ml(正常为150～250ng/ml),WBC16500/cmm,肌酸激酶950μ/L,乳酸脱氢酶279u/L,胸透、尿常规正常,头颅CT正常,甲状腺功能正常。入院第二天,出现铅管样肌强直,大汗,临床 The authors report a case of tricyclic antidepressants caused by malignant symptoms. Women, aged 58 and 50, underwent twitch with long-term depression. 7 months prior to admission, the first dose of desipramine 50mg at night, the amount of early treatment that is 100mg / day, due to the emergence of excitement and non-characteristic dyskinesia reduced to 50mg at night to hospital admission. 3 days before admission, there was agitation, anxiety, confusion, mild tremor, frequent buccal and lingual movements. Physical examination: normal muscle tone, no focal nervous system positive signs, laboratory tests found that desipramine concentration 111ng / ml (normal 150 ~ 250ng / ml), WBC16500 / cmm, creatine kinase 950μ / L, Dehydrogenase 279u / L, chest X-ray, normal urine, normal head CT, thyroid function is normal. The day after admission, lead tube-like muscle rigidity, sweating, clinical