Brigham医院复习胰头部导管细胞癌的病理学,发现约36％病例同时伴有胰体尾部肿瘤,主张以全胰切除替代Whipple手术,既可彻底切除肿瘤,又避免了胰瘘的危险,作者就此复习了48例胰导管细胞癌行全胰切除韵结果,1970～1976年期间死亡4例(死亡率18％),1977年后无住院死亡。全组中男性占60％,年龄30～70岁。25％病人术前有糖尿病,16％病人有结石。体格检查,95％病人有黄疸,230％能触到胆囊, Brigham Hospital reviewed the pathology of pancreatic head ductal cell carcinoma and found that approximately 36% of cases were accompanied by tumors of the pancreatic body and tail. Proposition of total pancreatectomy to replace Whipple surgery can completely remove the tumor and avoid the risk of pancreatic fistula. In this review, 48 cases of pancreatic ductal cell carcinoma underwent total pancreatectomy rhythm. From 1970 to 1976, 4 cases died (mortality 18%), and no hospital death occurred after 1977. Males accounted for 60% of the entire group, aged 30 to 70 years old. 25% of patients had diabetes before surgery and 16% had stones. Physical examination revealed that 95% of patients had jaundice and 230% had access to the gallbladder.