分化抑制因子(Id)是一组对碱性螺旋-环-螺旋(bHLH)转录因子活性起负调节作用的转录因子。哺乳动物含四种Id。自1990年发现Id分子以来,有关该分子在细胞发育成熟、增殖、分化、死亡和肿瘤发生等方面的作用已进行了广泛而深入的研究。作者重点针对Id与肿瘤发生、发展关系的研究进展作一综述。 Differentiation Inhibitors (Id) are a group of transcription factors that negatively regulate the activity of basic helix-loop-helix (bHLH) transcription factors. Mammals contain four types of Id. Since the discovery of the Id molecule in 1990, extensive and in-depth studies have been conducted on the role of this molecule in the maturation, proliferation, differentiation, death and tumorigenesis of the cell. The author focuses on the Id and tumor occurrence and development of research advances are reviewed.