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对我国北方胃癌高发区山东省临朐县一组３８００名随机人群进行胃癌及癌前病变的一级预防研究。目的：通过对有代表性的高危人群进行化学干预，筛选有效的胃癌干预剂，以降低胃癌癌前病变流行和胃癌死亡率，达到预防胃癌的目的。干预药物：ａ）用羟氨苄青霉素和洛赛克根除幽门螺杆菌（ＨＰ）感染；ｂ）每天服用ＶＥ、ＶＣ、硒等营养素；ｃ）每天服用大蒜素胶囊，服药期７年。用２３析因设计方法检测一种或多种联合干预作用。采用双盲法投药，已建立一支稳定的投药队伍负责每月一次发药和监督服药。研究结果：目前该组人群已服药一年多，服药依从率基本稳定在９０％以上，首次抗ＨＰ治疗的根除率６３．９％，二次治疗根除率为３３．９％，总疗效为７６．１％。
A primary prevention study of gastric cancer and precancerous lesions was performed on a group of 3,800 random people in Linfen County, Shandong Province, a high-risk area of gastric cancer in northern China. OBJECTIVE: To screen for effective gastric cancer intervention agents through chemical intervention in representative high-risk groups to reduce the precancerous lesions of gastric cancer and the mortality rate of gastric cancer so as to achieve the purpose of preventing gastric cancer. Intervention drugs: a) using amoxycillin and Losec to eradicate Helicobacter pylori (HP) infection; b) taking VE, VC, selenium and other nutrients every day; c) taking allicin capsules every day for 7 years. 23 factorial design methods were used to test one or more combined interventions. With a double-blind method of administration, a stable drug administration team has been established to take drugs once a month and supervise medication administration. Research results: At present, this group of people has been taking medication for more than one year, the compliance rate of medication has basically stabilized at more than 90%, the eradication rate of the first anti-HP treatment is 63.9%, the eradication rate of secondary treatment is 33.9%, and the total efficacy is 76. .1%.