常用的α_1-肾上腺素能受体拮抗剂的外周血管效应和有害的血流动力学结果,尤其是体位性低血压和反射性心动过速,阻碍α_1-肾上腺素能受体桔抗剂作为抗心律失常药的临床使用。本文研究了一种新的喹啉类α_1-肾上腺素能受体拮抗剂abanoquil(UK-52046)。abanoquil的化学名为4-氨基-6,7-二甲氧基-2-(1,2,3,4-四氢-6,7-二甲氧基异喹啉基-2)喹啉甲磺酸酯,它是一种作用于心脏和外周α_1-肾上腺素能受体的有效和选择性拮抗剂。对一系列动物的体内、外实验表明,在对血压几乎没有影响的剂量下,具有抗 Peripheral vascular effects and adverse hemodynamic effects of commonly used alpha 1 -adrenoceptor antagonists, particularly orthostatic hypotension and reflex tachycardia, block the alpha 1 -adrenergic receptor antagonist Clinical use of arrhythmic drugs. In this paper, a novel quinoloid α 1 -adrenoceptor antagonist abanoquil (UK-52046) was studied. The chemical name of abanoquil is 4-amino-6,7-dimethoxy-2- (1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolyl-2) quinoline Sulfonate, a potent and selective antagonist of alpha 1 -adrenoceptors acting on the heart and periphery. In vivo and in vitro experiments on a range of animals have shown that with doses that have little effect on blood pressure,