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吉非罗齐(gemfibrozil,GF)和洛伐他汀(lovas-tatin,LV)在分别单独使用时,大多数病人都能耐受.GF主要降低极低密度脂蛋白(VLDL)胆固醇和甘油三酯(TG)的水平,并升高高密度脂蛋白(HDL)胆固醇水平;此外,对低密度脂蛋白(LDL)胆固醇也有轻度的降低作用.LV主要降低LDL胆固醇水平,并对TG和HDL胆固醇具有中度升高作用.根据两药的效用特点和耐受性,合用两药看来可能是合理的,尤其在LDL胆固醇升高伴TG中度升高以及在HDL胆固醇降低时(Ⅱ_b型高脂血症).
Most patients tolerate gemfibrozil (GF) and lovastatin (LV) when used individually, and GF mainly decreases the levels of VLDL cholesterol and triglycerides (TG) and raise the level of high-density lipoprotein (HDL) cholesterol. In addition, it also has a slight decrease of low-density lipoprotein (LDL) cholesterol.LV mainly reduces the level of LDL cholesterol, and TG and HDL cholesterol Moderately elevated.According to the utility of the two drugs and tolerance, combined with two drugs may seem reasonable, especially in the LDL cholesterol with moderate increase in TG and cholesterol in HDL (Ⅱ_b type high Lipidemia).