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许多研究已发现金黄色葡萄球菌菌体表面的A蛋白有特异性吸收某些免疫球蛋白的功能。这一特性已在免疫学研究中得到广泛应用。Bansal等还发现A蛋白在恶性肿瘤患者的血清中能吸收某些免疫球蛋白(IgG)。本文以大肠癌为研究对象,采用表面富含A蛋白的金黄色葡萄球菌No1800株吸收患者血清中IgG,并与正常人、非肿瘤患者和良性肿瘤患者进行比较,观察大肠癌手术前后及随访时血清金葡菌A蛋白吸收IgG值的动态变化,现将结果报告如下:
Many studies have found that Protein A on the surface of Staphylococcus aureus specifically absorbs certain immunoglobulins. This feature has been widely used in immunology research. Bansal et al. also found that Protein A can absorb certain immunoglobulins (IgG) in the serum of patients with malignant tumors. In this study, colorectal cancer was used as the research object. S. aureus No1800 strain with surface protein A was used to absorb IgG in patients’ serum and compared with normal, non-tumor, and benign tumor patients. Colorectal cancer before and after surgery and follow-up was observed. The dynamic changes in the absorption of IgG in serum of S. aureus A protein are reported as follows: