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将消炎痛参入加温硫化型硅胶橡,制成均质型消炎痛释放系统,其消炎痛释放维持时间与消炎痛参入量有关。含6.4%与16%消炎痛的释放维持时间分别约为140天与378天。将含6.4%与16%消炎痛及空白释放装置植入大鼠子宫内30天或45天后,子宫组织学检查未见明显的损伤性变化。
Indomethacin into the heating curing silicone rubber, made of homogeneous type of indomethacin release system, the release of indomethacin maintenance time and the amount of indomethacin incorporated. The release maintenance time with 6.4% and 16% indomethacin was about 140 days and 378 days, respectively. Uterine histology did not show any significant lesion changes after implantation of 6.4% and 16% indomethacin and a blank release device into the uterus of rats for 30 days or 45 days.