论文部分内容阅读
目的:通过文献评价探讨白细胞介素-4(interleukin-4,IL-4)-590C/T基因多态性与慢性牙周炎(chronicperiodontitis,CP)易感性之间的关系。方法:检索8个数据库,搜集国内外有关病例对照研究文献。根据种族进行亚组分析,采用Meta分析评估IL-4基因多态性与CP的关联性,同时进行发表偏倚的检验和异质性分析,并对结果进行敏感性分析。结果:最终有8个研究纳入系统评价,病例组628例,健康对照组717例。Meta分析结果显示,IL-4基因-590C/T位点等位基因频率及基因多态性与研究人群CP易感性间均无显著相关性。进一步亚组分析显示,对于C等位基因而言,携带T等位基因增加了高加索人患CP的风险(C vs.T:OR=0.71,95%CI=0.56～0.89);高加索人种CP的易感性与-590C/T位点多态性显著相关(C vs.T:OR=0.71,95%CI=0.56～0.89;CC vs.CT:OR=0.60,95%CI=0.38～0.94;隐性模型CC vs.CT+TT:OR=0.61,95%CI=0.42～0.88),即高加索人中携带CC基因型者较携带CT与TT基因型者患CP风险减少39%,而亚洲人CP的易感性与该基因无显著相关性。结论:IL-4基因-590C/T位点多态性与高加索人CP易感性有一定相关性。这一结论尚需要大规模、多种族的流行病学研究加以验证。
Objective: To evaluate the relationship between interleukin-4 (IL-4) -590C / T polymorphism and the susceptibility to chronic periodontitis (CP) through literature evaluation. Methods: Eight databases were searched to collect literature about case control at home and abroad. Meta-analysis was used to assess the association of IL-4 gene polymorphism with CP in a subgroup analysis of ethnicity. Post hoc bias tests and heterogeneity analyzes were also performed, and the results were analyzed for sensitivity. Results: Finally, 8 studies were included in the systematic review, 628 cases and 717 healthy controls. Meta-analysis showed no significant correlation between IL-4 gene -590C / T allele frequency and gene polymorphism and CP susceptibility in study population. Further subgroup analyzes showed that carrying the T allele increased the risk of CP in Caucasians for C allele (C vs. T: OR = 0.71, 95% CI = 0.56 to 0.89); Caucasians CP (C vs. T: OR = 0.71, 95% CI = 0.56-0.89; CC vs. CT: OR = 0.60, 95% CI = 0.38-0.94; Implicit CC + CT + TT: OR = 0.61, 95% CI = 0.42-0.88). That is to say, the risk of CP reduction in Caucasians with CC genotypes was 39% lower than those with CT and TT genotypes. Asians The susceptibility of CP had no significant correlation with this gene. Conclusion: The -590C / T polymorphism of IL-4 gene is associated with susceptibility to Caucasian CP. This conclusion still needs large-scale, multi-ethnic epidemiological studies to be verified.