目的：评价孕妇血浆促肾上腺皮质激素释放激素（ＣＲＨ）水平在孕２８～３７周预测早产的临床价值。方法：采用放射免疫方法测定早产、足月产及过期产孕妇不同孕周血浆ＣＲＨ水平并随访跟踪观察。结果：足月产孕妇随着孕周的增加，在孕早、中期血浆ＣＲＨ水平无明显变化，在妊娠晚期ＣＲＨ水平升高显著。早产孕妇血浆ＣＲＨ水平明显高于同期正常孕妇血浆ＣＲＨ水平。结论：孕妇血浆ＣＲＨ测定可作为早产早期诊断的一个指标 Objective: To evaluate the clinical value of plasma corticotropin-releasing hormone (CRH) levels in pregnant women in predicting preterm birth at 28-37 weeks of gestation. Methods: Radioimmunoassay was used to measure plasma CRH levels in preterm, full term and overdue pregnant women at different gestational weeks and followed up. Results: Full-term pregnant women with gestational age increased in early pregnancy, mid-term plasma CRH levels did not change significantly in the third trimester CRH levels were significantly increased. The plasma CRH level of premature pregnant women was significantly higher than that of normal pregnant women in the same period. Conclusion: The determination of plasma CRH in pregnant women can be used as an indicator of early diagnosis of preterm labor