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2型糖尿病是一种慢性进行性疾病,多种因素皆可导致糖尿病患者B细胞凋亡和功能衰减,氧化应激对B细胞的损害是其中一个重要因素。众所周知,硫辛酸具有抗氧化应激作用,可以改善糖尿病周围神经病变[1-3],其是否可以保护胰岛B细胞功能是内分泌学科研究的热点。本研究主要目的是通过临床应用双向抗氧化应激药物α-硫辛酸制剂,观察其是否对胰岛B细胞具有保护作用。1资料与方法随机选择2011年8月至2012年8月入我院的空腹血
Type 2 diabetes mellitus is a chronic progressive disease. A variety of factors can lead to the attenuation of B cell apoptosis and function in diabetic patients. Oxidative stress on B cells is one of the important factors. It is well-known that lipoic acid has anti-oxidative stress effect and can improve diabetic peripheral neuropathy [1-3]. Whether it can protect islet B cell function is a hot topic in endocrinology research. The main purpose of this study is to observe whether it has a protective effect on islet B cells through the clinical application of the bi-directional anti-oxidant stress α-lipoic acid preparation. 1 Materials and Methods Random selection of August 2011 to August 2012 into our hospital fasting blood